Vol 6: Lymphomatoid Granulomatosis of Central Nervous System and Lung Driven by Epstein Barr Virus Proliferation: Successful Treatment with Rituximab-Containing Chemotherapy.Reportar como inadecuado



 Vol 6: Lymphomatoid Granulomatosis of Central Nervous System and Lung Driven by Epstein Barr Virus Proliferation: Successful Treatment with Rituximab-Containing Chemotherapy.


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This article is from Mediterranean Journal of Hematology and Infectious Diseases, volume 6.AbstractLymphomatoid granulomatosis LYG is a very rare Epstein-Barr virus EBV associated B-cell lymphoproliferative disorder. We report the case of a 41-year-old man who presented with fever and respiratory symptoms. Computed tomography showed multiple nodules in both lung fields. Polymerase chain reaction PCR analysis for EBV was positive in bronchoalveolar lavage and biopsy of lung node yielded a diagnosis of LYG, grade III. Shortly after initiation of treatment with agressive chemotherapy, neurological deterioration appeared. Neuroimaging findings revealed hydrocephalus and PCR analysis of the cerebrospinal fluid CSF was positive for EBV. Treatment with intravenous rituximab led to rapid reduction of EBV load in CSF, along with clinical and radiological improvement. After completion of treatment with immunochemotherapy, an autologous stem cell transplantation was performed. Patient stays in remission 18 months after diagnosis.



Autor: Fernandez-Alvarez, Ruben; Gonzalez, ME; Fernandez, Almudena; Gonzalez-Rodriguez, AP; Sancho, JM; Dominguez, Francisco; Fernandez, Carmen

Fuente: https://archive.org/







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