Vol 26: Lack of Association between PTPN22 Gene 1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population.Reportar como inadecuado



 Vol 26: Lack of Association between PTPN22 Gene  1858 C>T Polymorphism and Susceptibility to Generalized Vitiligo in a Turkish Population.


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This article is from Annals of Dermatology, volume 26.AbstractBackground: Vitiligo is an autoimmune polygenic disorder characterized by loss of pigmentation due to melanocyte destruction. The PTPN22 gene +1858 CT single nucleotide polymorphism rs2476601 has been shown to be associated with various autoimmune disorders. Objective: The aim of this study was to investigate whether the PTPN22 gene +1858 CT single nucleotide polymorphism is associated with susceptibility to generalized vitiligo in a Turkish population. Methods: One hundred and seven patients with generalized vitiligo, and one hundred and twelve gender-, age-, and ethnic-matched controls were enrolled in the study. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism. Results: The PTPN22 +1858 CT genotype and allele frequencies of the generalized vitiligo patients did not differ significantly from those of healthy controls. Conclusion: We found no association between the PTPN22 +1858 CT gene polymorphism and vitiligo susceptibility in Turkish generalized-vitiligo patients.



Autor: Akbas, Halit; Dertlioglu, Selma Bakar; Dilmec, Fuat; Atay, Ahmet Engin

Fuente: https://archive.org/







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