Vol 4: Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes.Reportar como inadecuado



 Vol 4: Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes.


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This article is from Scientific Reports, volume 4.AbstractTo investigate a possible methodology of exploiting herbal medicine and design polytherapy for the treatment of non-alcoholic fatty liver disease NAFLD, we have made use of Cichorium glandulosumBoiss et Huet CG, a traditional Chinese herbal medicine that has been proven to be effective in treating hepatic diseases. Here, we report that the extract of CG effectively reduced lipid accumulation under conditions of lipid overloading in vivo and in vitro in a rat high-fat diet model and a hepG2 cell model of free fatty acid treatment. CG extract also protected hepatocytes from injury and inflammation to aid its lipid-lowering properties in a rat high-fat diet model and a L02 cell model of acetaminophen treatment. Serum chemistry analysis accompanied by in vitro drug screening confirmed that CG-4, CG-10 and CG-14 are the lipo-effective components of CG. Western blotting analysis revealed that these components can regulate key lipid targets at the molecular level, including CD36, FATP5 and PPAR-α, thus the lipid oxidation and lipid absorption pathways. Finally, we adopted the experimental design and statistical method to calculate the best combination proportion CG-4: CG-10: CG-14 = 2.065: 1.782: 2.153 to optimize its therapeutic effect.



Autor: Ding, Lin; Liu, Jun-Lin; Hassan, Waseem; Wang, Lu-Lu; Yan, Fang-Rong; Shang, Jing

Fuente: https://archive.org/







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