Vol 10: Linear Superposition and Prediction of Bacterial Promoter Activity Dynamics in Complex Conditions.Reportar como inadecuado



 Vol 10: Linear Superposition and Prediction of Bacterial Promoter Activity Dynamics in Complex Conditions.


Vol 10: Linear Superposition and Prediction of Bacterial Promoter Activity Dynamics in Complex Conditions. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Descargar gratis o leer online en formato PDF el libro: Vol 10: Linear Superposition and Prediction of Bacterial Promoter Activity Dynamics in Complex Conditions.
This article is from PLoS Computational Biology, volume 10.AbstractBacteria often face complex environments. We asked how gene expression in complex conditions relates to expression in simpler conditions. To address this, we obtained accurate promoter activity dynamical measurements on 94 genes in E. coli in environments made up of all possible combinations of four nutrients and stresses. We find that the dynamics across conditions is well described by two principal component curves specific to each promoter. As a result, the promoter activity dynamics in a combination of conditions is a weighted average of the dynamics in each condition alone. The weights tend to sum up to approximately one. This weighted-average property, called linear superposition, allows predicting the promoter activity dynamics in a combination of conditions based on measurements of pairs of conditions. If these findings apply more generally, they can vastly reduce the number of experiments needed to understand how E. coli responds to the combinatorially huge space of possible environments.



Autor: Rothschild, Daphna; Dekel, Erez; Hausser, Jean; Bren, Anat; Aidelberg, Guy; Szekely, Pablo; Alon, Uri

Fuente: https://archive.org/







Documentos relacionados