Vol 4: Lactobacillus casei reduces susceptibility to type 2 diabetes via microbiota-mediated body chloride ion influx.Reportar como inadecuado



 Vol 4: Lactobacillus casei reduces susceptibility to type 2 diabetes via microbiota-mediated body chloride ion influx.


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This article is from Scientific Reports, volume 4.AbstractGut microbiota mediated low-grade inflammation is involved in the onset of type 2 diabetes T2DM. In this study, we used a high fat sucrose HFS diet-induced pre-insulin resistance and a low dose-STZ HFS rat models to study the effect and mechanism of Lactobacillus casei Zhang in protecting against T2DM onset. Hyperglycemia was favorably suppressed by L. casei Zhang treatment. Moreover, the hyperglycemia was connected with type 1 immune response, high plasma bile acids and urine chloride ion loss. This chloride ion loss was significantly prevented by L. casei via upregulating of chloride ion-dependent genes ClC1-7, GlyRα1, SLC26A3, SLC26A6, GABAAα1, Bestrophin-3 and CFTR. A shift in the caecal microflora, particularly the reduction of bile acid 7α-dehydroxylating bacteria, and fecal bile acid profiles also occurred. These change coincided with organ chloride influx. Thus, we postulate that the prevention of T2DM onset by L. casei Zhang may be via a microbiota-based bile acid-chloride exchange mechanism.



Autor: Zhang, Yong; Guo, Xiao; Guo, Jianlin; He, Qiuwen; Li, He; Song, Yuqin; Zhang, Heping

Fuente: https://archive.org/



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