Vol 3: LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.Reportar como inadecuado



 Vol 3: LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.


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This article is from eLife, volume 3.AbstractTranscriptional elongation by RNA polymerase Pol II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b P-TEFb stimulates transcriptional elongation by phosphorylating Pol II and antagonizing negative elongation factors. A reservoir of P-TEFb is sequestered in the inactive 7SK snRNP where 7SK snRNA and the La-related protein LARP7 are required for the integrity of this complex. Here, we show that P-TEFb activity is important for the epithelial–mesenchymal transition EMT and breast cancer progression. Decreased levels of LARP7 and 7SK snRNA redistribute P-TEFb to the transcriptionally active super elongation complex, resulting in P-TEFb activation and increased transcription of EMT transcription factors, including Slug, FOXC2, ZEB2, and Twist1, to promote breast cancer EMT, invasion, and metastasis. Our data provide the first demonstration that the transcription elongation machinery plays a key role in promoting breast cancer progression by directly controlling the expression of upstream EMT regulators.DOI:http:-dx.doi.org-10.7554-eLife.02907.001



Autor: Ji, Xiaodan; Lu, Huasong; Zhou, Qiang; Luo, Kunxin

Fuente: https://archive.org/



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