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 Vol 4: Interaction of Mason-Pfizer monkey virus matrix protein with plasma membrane.


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This article is from Frontiers in Microbiology, volume 4.AbstractBudding is the final step of the late phase of retroviral life cycle. It begins with the interaction of Gag precursor with plasma membrane PM through its N-terminal domain, the matrix protein MA. However, single genera of Retroviridae family differ in the way how they interact with PM. While in case of Lentiviruses e.g., human immunodeficiency virus the structural polyprotein precursor Gag interacts with cellular membrane prior to the assembly, Betaretroviruses Mason-Pfizer monkey virus M-PMV first assemble their virus-like particles VLPs in the pericentriolar region of the infected cell and therefore, already assembled particles interact with the membrane. Although both these types of retroviruses use similar mechanism of the interaction of Gag with the membrane, the difference in the site of assembly leads to some differences in the mechanism of the interaction. Here we describe the interaction of M-PMV MA with PM with emphasis on the structural aspects of the interaction with single phospholipids.



Autor: Prchal, Jan; Kroupa, Tomas; Ruml, Tomas; Hrabal, Richard

Fuente: https://archive.org/



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