Vol 9: IFN Serum Levels Are Associated with Endothelial Progenitor Cells Imbalance and Disease Features in Rheumatoid Arthritis Patients.Reportar como inadecuado



 Vol 9: IFN Serum Levels Are Associated with Endothelial Progenitor Cells Imbalance and Disease Features in Rheumatoid Arthritis Patients.


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This article is from PLoS ONE, volume 9.AbstractIntroduction: IFNα has been largely implicated in the ethiopathogenesis of autoimmune diseases but only recently it has been linked to endothelial damage and accelerated atherosclerosis in autoimmunity. In addition, proinflammatory conditions are supposed to be implicated in the cardiovascular status of these patients. Since a role for IFNα in endothelial damage and impaired Endothelial Progenitor Cell EPC number and function has been reported in other diseases, we aimed to evaluate the potential associations of IFNα serum levels on EPC populations and cytokine profiles in Rheumatoid Arthritis RA patients. Methods: pre-EPC, EPC and mature EPC mEPC populations were quantified by flow cytometry analyzing their differential CD34, CD133 and VEGFR2 expression in blood samples from 120 RA patients, 52 healthy controls HC, and 83 systemic lupus erythematosus SLE patients as disease control. Cytokine serum levels were measured by immunoassays and clinical and immunological data, including cardiovascular CV events and CV risk factors, were retrospectively obtained by reviewing clinical records. Results: Long-standing, but not recent onset RA patients displayed a significant depletion of all endothelial progenitor populations, unless high IFNα levels were present. In fact, the IFNhigh RA patient group n = 40, 33%, showed increased EPC levels, comparable to SLE patients. In addition, high IFNα serum levels were associated with higher disease activity DAS28, presence of autoantibodies, higher levels of IL-1β, IL-6, IL-10 and MIP-1α, lower amounts of TGF-β, and increased mEPC-EPC ratio, thus suggesting higher rates of endothelial damage and an endothelial repair failure. Finally, the relationship between high IFNα levels and occurrence of CV events observed in RA patients seems to support this hypothesis. Conclusions: IFNα serum marker could be used to identify a group of RA patients with increased disease activity, EPC imbalance, enhanced proinflammatory profile and higher cardiovascular risk, probably due, at least in part, to an impaired endothelial repair.



Autor: Rodriguez-Carrio, Javier; de Paz, Banesa; Lopez, Patricia; Prado, Catuxa; Alperi-Lopez, Mercedes; Ballina-Garcia, Francisco Javier; Suarez, Ana

Fuente: https://archive.org/



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