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 Vol 14: Inverse correlation between serum interleukin-6 and iron levels among Japanese adults: a cross-sectional study.


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This article is from BMC Hematology, volume 14.AbstractBackground: Interleukin-6 IL-6 is a multifunctional cytokine that is produced by many different cell types, and plays an important role in the regulation of inflammation, immune responses, the acute-phase response, and hematopoiesis. Previous laboratory and clinical studies have shown that IL-6 causes a significant decrease in serum iron levels. Therefore, we conducted an epidemiological study to examine the association between serum IL-6 and iron levels. Methods: In total, 280 Japanese individuals aged 20–78 years were enrolled when they visited a clinic located in an urban area for Helicobacter pylori H. pylori infection tests and subsequent eradication; 65.3% were infected with H. pylori. Subjects with gastric cancer, idiopathic thrombocytopenia, or IL-6  10 pg-mL were excluded from the study. Serum iron and IL-6 levels were measured using the 2-nitroso-5-N-propyl-3-sulfopropylamino phenol method and chemiluminescence enzyme immunoassay, respectively. Results: Geometric mean iron and IL-6 levels were 111.5 μg-dL and 1.77 pg-mL, respectively, for men, and 89.4 μg-dL and 1.55 pg-mL, respectively, for women. The logarithm of serum iron levels was negatively correlated with the logarithm of IL-6 levels in men r = −0.19, p = 0.047, but not in women r = −0.035, p = 0.65. Regression analysis, adjusted for sex, age, and H. pylori infection status, showed that the logarithm of serum iron levels was significantly associated with a decreased logarithm of IL-6 levels β = −0.053, p = 0.041. The odds ratio for low serum iron levels adjusted for sex, age, and H. pylori infection status was 7.88 95% CI 1.29–48.06 in those with an IL-6 level  4 pg-mL. Conclusion: Lower serum iron levels are significantly associated with higher serum IL-6 levels among Japanese adults.



Autor: Nakagawa, Hiroko; Tamura, Takashi; Mitsuda, Yoko; Goto, Yasuyuki; Kamiya, Yoshikazu; Kondo, Takaaki; Wakai, Kenji; Hamajima, Nobuyuki

Fuente: https://archive.org/







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