Vol 4: Increased expression of p62-SQSTM1 in prion diseases and its association with pathogenic prion protein.Reportar como inadecuado



 Vol 4: Increased expression of p62-SQSTM1 in prion diseases and its association with pathogenic prion protein.


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This article is from Scientific Reports, volume 4.AbstractPrion diseases are neurodegenerative disorders characterized by the aggregation of abnormally folded prion protein PrPSc. In this study, we focused on the mechanism of clearance of PrPSc, which remains unclear. p62 is a cytosolic protein known to mediate both the formation and degradation of aggregates of abnormal proteins. The levels of p62 protein increased in prion-infected brains and persistently infected cell cultures. Upon proteasome inhibition, p62 co-localized with PrPSc, forming a large aggregate in the perinuclear region, hereafter referred to as PrPSc-aggresome. These aggregates were surrounded with autophagosome marker LC3 and lysosomes in prion-infected cells. Moreover, transient expression of the phosphomimic form of p62, which has enhanced ubiquitin-binding activity, reduced the amount of PrPSc in prion-infected cells, indicating that the activation of p62 could accelerate the clearance of PrPSc. Our findings would thus suggest that p62 could be a target for the therapeutic control of prion diseases.



Autor: Homma, Takujiro; Ishibashi, Daisuke; Nakagaki, Takehiro; Satoh, Katsuya; Sano, Kazunori; Atarashi, Ryuichiro; Nishida, Noriyuki

Fuente: https://archive.org/







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