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Journal of Cardiothoracic Surgery

, 5:98

First Online: 02 November 2010Received: 16 May 2010Accepted: 02 November 2010


BackgroundHemodynamic function may be depressed in the early postoperative stages after cardiac surgery. The aim of this study was the analysis of the myocardial contractility in neonates after cardiopulmonary bypass CPB and mild hypothermia.

MethodsThree indices of left ventricular myocardial contractile function dP-dt, dP-dt-P, and wall thickening were studied up to 6 hours after CPB in neonatal piglets CPB group; n = 4. The contractility data were analysed and then compared to the data of newborn piglets who also underwent median thoracotomy and instrumentation for the same time intervals but without CPB non-CPB group; n = 3.

ResultsLeft ventricular dP-dtmax and dP-dtmax-P remained stable in CPB group, while dP-dtmax decreased in non-CPB group 5 hours postoperatively 1761 ± 205 mmHg-s at baseline vs. 1170 ± 205 mmHg-s after 5 h; p < 0.05. However, with regard to dP-dtmax and dP-dtmax-P there were no statistically significant differences between the two groups. Comparably, although myocardial thickening decreased in the non-CPB group the differences between the two groups were not statistically significant.

ConclusionsThe myocardial contractile function in survived neonatal piglets remained stable 6 hours after cardiopulmonary bypass and mild hypothermia probably due to regional hypercontractility.

Electronic supplementary materialThe online version of this article doi:10.1186-1749-8090-5-98 contains supplementary material, which is available to authorized users.

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Autor: Theodor Tirilomis - Oliver J. Liakopoulos - K. Oguz Coskun - Marc Bensch - Aron-Frederik Popov - Jan D. Schmitto - Friedr


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