Influence of diet enriched with conjugated linoleic acids on their distribution in tissues of rats with DMBA induced tumorsReportar como inadecuado




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Lipids in Health and Disease

, 9:126

First Online: 02 November 2010Received: 01 October 2010Accepted: 02 November 2010

Abstract

BackroundConjugated linoleic acids CLA are a group of positional and geometric isomers of linoleic acid with proven beneficial influence on health. They show e.g. anticarcinogenic, antiobesity, and antiatherogenic effect. Milk, dairy products and meat of poligastric animals are their most valuable dietary sources, with cis-9, trans-11 CLA RA - rumenic acid being the predominant isomer. Dietary supplements with CLA became very popular, mainly among the overweight and bodybuilders.

The aim of this study was to examine the influence of the food supplements with conjugated linoleic acid on carcinogenesis in female Sprague-Dawley rats and evaluation of CLA and other fatty acids distribution in their bodies.

Animals were divided into four groups depending on the diet supplementation oil or Bio-C.L.A. Pharma Nord Denmark given intragastrically and presence or absence of carcinogenic agent 7,12-dimethylbenzaantharcene. Animals were decapitated at 21st week of experiment and serum and microsomes were extracted.

Results and conclusionsThe mammary tumours adenocarcinoma occurred in groups treated with DMBA. Diet enriched with CLA decreased the cancer morbidity 67% in Bio-C.L.A. compared to 88% in oil and delayed the cancer induction p = 0.0018. There were no differences in body and organs weight.

The supplement used in the study was a mixture of several fatty acids with the greatest proportion of CLA isomers: trans-10, cis-12 33% and cis-9, trans-11 31%. Both of them were present in tissues but the content of rumenic acid was greater. Dietary supplementation had also significant impact on other fatty acids content, both in serum and in microsomes.

AbbreviationsCLAConjugated linoleic acid

RARumenic acid

FAMEFatty acid methyl ester

DMBA7,12-dimethylbenzaanthracene

GCgas chromatography

DHADocosahexaenoic acid

EPAEicosapentaenoic acid

AAArachidonic acid

LALinoleic acid

ALAα-linolenic acid

Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-9-126 contains supplementary material, which is available to authorized users.

Andrzej Tokarz, Agnieszka Dudek, Weronika Kazimierska and Wojciech Bielecki contributed equally to this work.

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Autor: Agnieszka Białek - Andrzej Tokarz - Agnieszka Dudek - Weronika Kazimierska - Wojciech Bielecki

Fuente: https://link.springer.com/







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