Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatmentReportar como inadecuado




Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Allergy, Asthma and Clinical Immunology

, 6:28

First Online: 02 November 2010Received: 17 June 2010Accepted: 02 November 2010

Abstract

BackgroundOsteopontin OPN is a multifunctional cytokine that has been primarily investigated in Th1 diseases. Recently, it has also been implicated in Th2-mediated allergic diseases, such as asthma. The expression of OPN in allergic rhinitis AR is currently unknown, as is the effect of intranasal glucocorticosteroids GCs on that expression.

MethodsSubjects with AR were randomised to receive treatment with fluticasone propionate FP n = 12 or a placebo n = 16 over the grass pollen season and nasal biopsies were taken prior to, and during the season. OPN expression in the nasal mucosa was examined with immunohistochemistry. Healthy non-AR controls n = 5 were used as a comparator.

ResultsOPN expression was detected in epithelial cells, subepithelial infiltrating-inflammatory cells and cells lining the vessels and glands of all subjects. Comparison of the pre- and peak-pollen season biopsy sections in placebo treated patients revealed no increase in OPN expression during the grass pollen season 5.7% vs 6.4%. Treatment with a local glucocorticosteroid did not alter the expression of OPN during pollen exposure 6.2% vs 6.7%.

ConclusionOPN has been increasingly associated with the pathogenesis of various Th2-mediated diseases. However, our finding that the OPN expression in the nasal mucosa of AR patients is not significantly affected by allergen exposure and is comparable to that of the healthy controls, suggests that intracellular OPN is not directly involved in the pathogenesis of allergic rhinitis.

Electronic supplementary materialThe online version of this article doi:10.1186-1710-1492-6-28 contains supplementary material, which is available to authorized users.

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Autor: Serena E O-Neil - Carina Malmhäll - Konstantinos Samitas - Teet Pullerits - Apostolos Bossios - Jan Lötvall

Fuente: https://link.springer.com/







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