RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximabReportar como inadecuado




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Radiation Oncology

, 5:102

First Online: 03 November 2010Received: 02 September 2010Accepted: 03 November 2010

Abstract

BackgroundLocal control in adjuvant-definitive RT of adenoid cystic carcinoma ACC is largely dose-dependent. However, some clinical situations do not allow application of tumouricidal doses i.e. re-irradiation hence radiation sensitization by exploitation of high endothelial growth factor receptor EGFR-expression in ACC seems beneficial. This is a single-institution experience of combined radioimmunotherapy RIT with the EGFR-inhibitor cetuximab.

MethodsBetween 2006 and 2010, 9 pts received RIT for advanced-recurrent ACC, 5-9 pts as re-irradiation. Baseline characteristics as well as treatment parameters were retrieved to evaluate efficacy and toxicity of the combination regimen were evaluated. Control rates local-distant and overall survival were calculated using Kaplan-Meier estimation.

ResultsMedian dose was 65 Gy, pts received a median of 6 cycles cetuximab. RIT was tolerated well with only one °III mucositis-dysphagia. Overall response-remission rates were high 77,8%; 2-year estimate of local control was 80% hence reaching local control levels comparable to high-dose RT. Progression-free survival PFS at 2 years and median overall survival were only 62,5% and 22,2 mo respectively.

ConclusionWhile local control and treatment response in RIT seems promising, PFS and overall survival are still hampered by distant failure. The potential benefit of RIT with cetuximab warrants exploration in a prospective controlled clinical trial.

Electronic supplementary materialThe online version of this article doi:10.1186-1748-717X-5-102 contains supplementary material, which is available to authorized users.

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Autor: Alexandra D Jensen - Jürgen Krauss - Wilko Weichert - Jürgen Debus - Marc W Münter

Fuente: https://link.springer.com/







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