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Virology Journal

, 7:298

First Online: 03 November 2010Received: 22 September 2010Accepted: 03 November 2010


The application of gene therapy for malignant gliomas is still under study and the use of specific vectors represents an important contribution. Here, we investigated bovine herpesvirus 4 BoHV-4, which is non-pathogenic if injected into the rodent brain. We show that the vector can infect mouse, rat and human glioma cell lines and primary cultures obtained from human glioblastoma in vitro. BoHV-4 was injected into a tumour grown in rat brain. Although virus expression was scattered across the tumour mass, it was mainly located in the peripheral area of larger gliomas. These data support BoHV-4 as a candidate vector for glioma treatment.

List of abbreviationsBoHV-4Bovine herpesvirus 4

CPECytopathic effect

CGMComplete growth medium

RMSRostral migratory stream

DMEMDulbecco Modified Eagle-s Medium

EGFPEnhanced green fluorescent protein

FBSFetal bovine serum

Electronic supplementary materialThe online version of this article doi:10.1186-1743-422X-7-298 contains supplementary material, which is available to authorized users.

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Autor: Marco Redaelli - Carla Mucignat-Caretta - Andrea Cavaggioni - Antonio Caretta - Domenico D-Avella - Luca Denaro - Sandro Ca


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