Metabolic syndrome is linked to a mild elevation in liver aminotransferases in diabetic patients with undetectable non-alcoholic fatty liver disease by ultrasoundReportar como inadecuado




Metabolic syndrome is linked to a mild elevation in liver aminotransferases in diabetic patients with undetectable non-alcoholic fatty liver disease by ultrasound - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Diabetology and Metabolic Syndrome

, 2:65

First Online: 03 November 2010Received: 13 June 2010Accepted: 03 November 2010

Abstract

BackgroundDespite ongoing findings on the relationship between elevated levels of alanine and aspartate aminotransferases ALT and AST and metabolic syndrome MetS, this association in diabetic patients without a known cause for liver enzymes elevation other than diabetes, per se, remains unclear. In this study, we aimed to assess the relationship between circulating liver enzymes and MetS in a relatively large sample of patients with diabetes.

MethodsA total of 670 diabetic patients, without known causes of hepatocellular injury, were enrolled. Patients with ultrasonographic signs of fatty liver disease were not included. Fasting blood samples were obtained and biochemical characteristics were measured. MetS was defined according to the international diabetes federation criteria.

ResultsSerum ALT and AST were significantly higher in patients with MetS p < 0.001. High waist circumference and low HDL-cholesterol were significantly associated with elevated ALT OR = 2.56 and 2.0, respectively and AST OR = 2.23 and 2.21, respectively. ALT and AST were significantly associated with MetS OR = 2.17 and 2.31, respectively. These associations remained significant after multiple adjustments for age, sex, BMI, diabetes duration, HbA1c and medications. There was a significant p < 0.01 positive association between the number of the MetS features and the level of ALT or AST.

ConclusionIn diabetic patients without ultrasonographic evidence of fatty liver, elevated aminotransferases are independently associated with MetS. Despite negative ultrasound results in diabetic patients with MetS, the serum level of liver aminotransferases may be elevated and should be more thoroughly monitored.

Electronic supplementary materialThe online version of this article doi:10.1186-1758-5996-2-65 contains supplementary material, which is available to authorized users.

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Autor: Alireza Esteghamati - Arsia Jamali - Omid Khalilzadeh - Sina Noshad - Mohammad Khalili - Ali Zandieh - Afsaneh Morteza - Ma

Fuente: https://link.springer.com/



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