Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settingsReportar como inadecuado

Baseline severe anaemia should not preclude use of zidovudine in antiretroviral-eligible patients in resource-limited settings - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of the International AIDS Society

, 13:42

First Online: 03 November 2010Received: 07 April 2010Accepted: 03 November 2010


BackgroundStavudine is no longer recommended as part of first-line therapy for patients initiating antiretroviral therapy ART in Uganda. Most patients are currently initiated on zidovudine-containing regimens, which can induce anaemia. We investigated the risk factors for early severe anaemia in the first six months of ART initiation.

MethodsWe defined baseline ART initiation anaemia as haemoglobin Hb ≤9.5 g-dL, baseline severe anaemia as Hb ≤8 g-dL, and early severe anaemia as Hb ≤8 g-dL within six months of ART initiation. Risk factors for the development of early severe anaemia were analyzed using a multivariable logistic regression model.

ResultsIn total, 5494 patients initiated ART, 821 15% had baseline anaemia, and 296 5% had baseline severe anaemia. Early severe anaemia occurred in 109 4% of 3105 patients who had at least one Hb measurement in the first six months on ART. Patients with baseline anaemia had a larger increase in Hb median g-dL IQR within the first six months compared with non-anaemic patients 2.9 1.7, 4.6 vs. 0.7 -0.2, 1.7, p < 0.0001. Having a new tuberculosis episode OR 3.69 95% CI 1.64 - 8.32, MCV <80fL OR 1.60 95% CI 1.01- 2.52 and baseline severe anaemia OR 5.27 95% CI 3.00 - 9.26 were associated with early severe anaemia. Initiation on a zidovudine-based regimen was not associated with an increased risk of early severe anaemia.

ConclusionsAmong patients in an urban HIV clinic in Uganda, severe anaemia is modestly prevalent at ART initiation and improves with ART in the majority of patients. These data suggest that baseline severe anaemia should not be used as a criterion for avoiding the use of zidovudine in patients initiating ART in resource-limited settings.

Electronic supplementary materialThe online version of this article doi:10.1186-1758-2652-13-42 contains supplementary material, which is available to authorized users.

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Autor: Agnes N Kiragga - Barbara Castelnuovo - Damalie Nakanjako - Yukari C Manabe


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