Is standard breast-conserving therapy BCT in elderly breast cancer patients justified A prospective measurement of acute toxicity according CTC-classificationReportar como inadecuado




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Radiation Oncology

, 5:103

First Online: 04 November 2010Received: 28 June 2010Accepted: 04 November 2010

Abstract

BackgroundBreast conserving therapy BCT is an accepted treatment for early-stage breast cancer. This study aimed to measure prospectively acute radiation-related toxicity and to create a comprehensive data base for long-term temporal analyses of 3D conformal adjuvant radiotherapy. The specific aspect of age has been neglected by traditional research. Therefore, the impact of age on acute BCT toxicity should be also specifically adressed.

MethodsToxicity was measured in 109 patients at initiation t1, during radiotherapy t2-t7, and 6 weeks after treatment completion t8 using a new topographic module. Organ systems were recorded in 15 scales and scored according to symptom intensity grade 0-5 based on CTC Common Toxicity Criteria -classification. Radiotherapy was virtually CT-based planned and applied with 6-MeV-photons. Mean total dose was 60.1 Gy. Patients were stratified by age in 3 Groups: <50, 50-60, and >60 years.

ResultsRegistered toxicity was generally low. Mean overall-grade climbed from 0.29-0.40 t1-t7, and dropped to 0.23 t8. Univariate analyses revealed slightly higher toxicity in older > 60 years versus young patients < 50 years in 2 scales only: breast-symmetry p = 0.033, and arm function p = 0.007. However, in the scale -appetite- toxicity was higher in younger < 50 years versus older > 60 years patients p = 0.039. Toxicity differences in all other scales were not significant. Between older > 60 years and midaged patients 50-60 years no significant differences in toxicity were found. This was also true for the comparison between young < 50 years versus midaged patient groups 50-60 years.

ConclusionThe treatment concept of BCT for breast cancer is generally well tolerated. The toxicity-measurement with the new topographic module is feasible. Not modified standard treatment for BC should be performed in elderly women.

Electronic supplementary materialThe online version of this article doi:10.1186-1748-717X-5-103 contains supplementary material, which is available to authorized users.

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Autor: Razvan M Galalae - Jürgen Schultze - Kirsten Eilf - Bernhard Kimmig

Fuente: https://link.springer.com/







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