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Lipids in Health and Disease

, 9:134

First Online: 23 November 2010Received: 03 November 2010Accepted: 23 November 2010

Abstract

BackgroundKurozu concentrated liquid KCL is used as a health-promoting supplement for the treatment of disorders such as cancer, hyperlipidemia, and hypertension in Japan. We investigated the possible anti-obesity effects of KCL in rats.

MethodsMale Sprague Dawley rats were fed American Institute of Nutrition 76 formula diet and were orally administrated KCL or acetic acid at a dose of 100 mg-kg body weight or deionized water for 4 weeks. Adipocyte size, DNA content in subcutaneous adipose tissue, lipid levels in the serum and liver, and the rate of fatty acid excretion were determined. Effects of KCL on pancreatic lipase activity and 3T3-L1 preadipocyte differentiation were investigated in vitro.

ResultsIn the KCL group, the average adipocyte size in subcutaneous and perirenal adipose tissues was significantly reduced. The KCL-administered rats displayed greater numbers of small adipocytes in the subcutaneous, perirenal and mesenteric adipose tissues than did rats from the other groups. In the KCL group, the DNA content in subcutaneous adipose tissue was significantly increased. The rate of fatty acid excretion was significantly increased in the KCL group. Furthermore, KCL significantly inhibited pancreatic lipase activity in vitro, and also significantly inhibited fat accumulation and mRNA expression of fatty acid binding protein 2 aP2 and peroxisome proliferator-activated γ PPARγ in 3T3-L1 preadipocyte. The levels of serum and liver lipids, the concentration of serum glucose, and the levels of adiponectin were similar among the 3 groups.

ConclusionOral administration of KCL decreases the adipocyte size via inhibition of dietary fat absorption and reductions of PPARγ and aP2 mRNA expression levels in adipocytes.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-9-134 contains supplementary material, which is available to authorized users.

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Autor: Li-Tao Tong - Yoshinori Katakura - Sayaka Kawamura - Sanae Baba - Yasutake Tanaka - Miyako Udono - Yoshie Kondo - Kumi Nak

Fuente: https://link.springer.com/



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