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Journal of Cardiothoracic Surgery

, 5:116

First Online: 23 November 2010Received: 03 August 2010Accepted: 23 November 2010

Abstract

BackgroundTo explore the pathological changes of three-dimension structure of ventricular myocardial fibers after anterior myocardial infarction in dog heart.

MethodsFourteen acute anterior myocardial infarction models were made from healthy dogs mean weight 17.6 ± 2.5 kg. Six out of 14 dogs with old myocardial infarction were sacrificed, and their hearts were harvested after they survived the acute anterior myocardial infarction for 3 months. Each heart was dissected into ventricular myocardial band VMB, morphological characters in infarction region were observed, and infarct size percents in descending segment and ascending segment were calculated.

ResultsSix dog hearts were successfully dissected into VMB. Uncorresponding damages in myocardial fibers of descending segment and ascending segment were found in apical circle in anterior wall infarction. Infarct size percent in the ascending segment was significantly larger than that in the descending segment 23.36 ± 3.15 SD vs 30.69 ± 2.40%, P = 0.0033; the long axis of infarction area was perpendicular to the orientation of myocardial fibers in ascending segment; however, the long axis of the infarction area was parallel with the orientation of myocardial fibers in descending segment.

ConclusionsWe found that damages were different in both morphology and size in ascending segment and descending segment in heart with myocardial infarction. This may provide an important insight for us to understand the mechanism of heart failure following coronary artery diseases.

Electronic supplementary materialThe online version of this article doi:10.1186-1749-8090-5-116 contains supplementary material, which is available to authorized users.

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Autor: Changqing Gao - Weihua Ye - Libin Li

Fuente: https://link.springer.com/







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