Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban centerReportar como inadecuado

Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Respiratory Research

, 11:167

First Online: 01 December 2010Received: 09 August 2010Accepted: 01 December 2010


BackgroundThe causation of asthma is poorly understood. Risk factors for atopic and non-atopic asthma may be different. This study aimed to analyze the associations between markers of poverty, dirt and infections and wheezing in atopic and non-atopic children.

Methods1445 children were recruited from a population-based cohort in Salvador, Brazil. Wheezing was assessed using the ISAAC questionnaire and atopy defined as allergen-specific IgE ≥0.70 kU-L. Relevant social factors, environmental exposures and serological markers for childhood infections were investigated as risk factors using multivariate multinomial logistic regression.

ResultsCommon risk factors for wheezing in atopic and non-atopic children, respectively, were parental asthma and respiratory infection in early childhood. No other factor was associated with wheezing in atopic children. Factors associated with wheezing in non-atopics were low maternal educational level OR 1.49, 95% CI 0.98-2.38, low frequency of room cleaning OR 2.49, 95% CI 1.27-4.90, presence of rodents in the house OR 1.48, 95% CI 1.06-2.09, and day care attendance OR 1.52, 95% CI 1.01-2.29.

ConclusionsNon-atopic wheezing was associated with risk factors indicative of poverty, dirt and infections. Further research is required to more precisely define the mediating exposures and the mechanisms by which they may cause non-atopic wheeze.

Electronic supplementary materialThe online version of this article doi:10.1186-1465-9921-11-167 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Autor: Mauricio L Barreto - Sergio S Cunha - Rosemeire Fiaccone - Renata Esquivel - Leila D Amorim - Sheila Alvim - Matildes Pr

Fuente: https://link.springer.com/

Documentos relacionados