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BMC Plant Biology

, 10:285

First Online: 22 December 2010Received: 03 August 2010Accepted: 22 December 2010


BackgroundThroughout their lives plants produce new organs from groups of pluripotent cells called meristems, located at the tips of the shoot and the root. The size of the shoot meristem is tightly controlled by a feedback loop, which involves the homeodomain transcription factor WUSCHEL WUS and the CLAVATA CLV proteins. This regulatory circuit is further fine-tuned by morphogenic signals such as hormones and sugars.

ResultsHere we show that a family of four plant-specific proteins, encoded by the FANTASTIC FOUR FAF genes, has the potential to regulate shoot meristem size in Arabidopsis thaliana. FAF2 and FAF4 are expressed in the centre of the shoot meristem, overlapping with the site of WUS expression. Consistent with a regulatory interaction between the FAF gene family and WUS, our experiments indicate that the FAFs can repress WUS, which ultimately leads to an arrest of meristem activity in FAF overexpressing lines. The finding that meristematic expression of FAF2 and FAF4 is under negative control by CLV3 further supports the hypothesis that the FAFs are modulators of the genetic circuit that regulates the meristem.

ConclusionThis study reports the initial characterization of the Arabidopsis thaliana FAF gene family. Our data indicate that the FAF genes form a plant specific gene family, the members of which have the potential to regulate the size of the shoot meristem by modulating the CLV3-WUS feedback loop.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2229-10-285 contains supplementary material, which is available to authorized users.

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Autor: Vanessa Wahl - Luise H Brand - Ya-Long Guo - Markus Schmid


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