Toxicity of daily low dose cisplatin in radiochemotherapy for locally advanced head and neck cancerReportar como inadecuado




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Journal of Cancer Research and Clinical Oncology

, Volume 135, Issue 7, pp 961–967

First Online: 24 December 2008Received: 14 October 2008Accepted: 04 December 2008

Abstract

PurposeTo evaluate toxicity of radiochemotherapy schedule using daily-low-dose-cisplatin in radiochemotherapy of locally-advanced head-and-neck-cancer HNSCC.

Methods and patientsFrom October 2003 to October 2006, 50 patients with HNSCC stage III-IVA-IVB were treated. In 32 patients, surgery and adjuvant radiotherapy64 Gy, in 18 patients definitive radiotherapy70 Gy was performed. Low-dose-cisplatin was applied concomitantly 6 mg-m-every radiotherapy-day.

ResultsAcute toxicity ≥grade 3 was observed in 22 patients 11 patients mucositis-dysphagia, 7 hematologic toxicity, 4 mucositis-dysphagia-hematologic toxicity. 90% of our patients received >80% of the planned cumulative chemotherapy dose, 94% the intended dose of radiotherapy. After median follow-up of 24.2 months, 3-year overall survival and loco-regional control rates were 67.1 and 78%. During follow-up, chronic toxicity ≥grade 3 xerostomia, subcutaneous fibrosis, or lymphedema was observed in nine patients.

ConclusionWe found chemoradiation with daily-low-dose-cisplatin to be feasible with advantage of low acute and chronic toxicity. Therefore, use of low-dose-cisplatin should be evaluated in future clinical trials.

KeywordsLow dose cisplatin HNSCC Radiochemotherapy Toxicity  Download fulltext PDF



Autor: Hendrik Andreas Wolff - Tobias Overbeck - Ralph M. Roedel - Robert M. Hermann - Markus K. A. Herrmann - Tereza Kertesz

Fuente: https://link.springer.com/







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