# Random Matrix approach to collective behavior and bulk universality in protein dynamics - Quantitative Biology > Quantitative Methods

Random Matrix approach to collective behavior and bulk universality in protein dynamics - Quantitative Biology > Quantitative Methods - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Abstract: Covariance matrices of amino acid displacements, commonly used tocharacterize the large-scale movements of proteins, are investigated throughthe prism of Random Matrix Theory. Bulk universality is detected in the localspacing statistics of noise-dressed eigenmodes, which is well described by aBrody distribution with parameter $\beta\simeq 0.8$. This finding, supported byother consistent indicators, implies a novel quantitative criterion to singleout the collective degrees of freedom of the protein from the majority ofhigh-energy, localized vibrations.

Autor: Raffaello Potestio, Fabio Caccioli, Pierpaolo Vivo

Fuente: https://arxiv.org/