Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary diseaseReportar como inadecuado

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Particle and Fibre Toxicology

, 6:25

First Online: 26 September 2009Received: 05 May 2009Accepted: 26 September 2009


BackgroundGrowing evidence indicates that ambient air pollution is associated with exacerbation of chronic diseases like chronic pulmonary disease. A prospective panel study was conducted to investigate short-term changes of blood markers of inflammation and coagulation in response to daily changes in air pollution in Erfurt, Germany. 12 clinical visits were scheduled and blood parameters were measured in 38 male patients with chronic pulmonary disease during winter 2001-2002. Additive mixed models with random patient intercept were applied, adjusting for trend, weekday, and meteorological parameters. Hourly data on ultrafine particles UFP, 0.01-0.1 μm, accumulation mode particles ACP, 0.1-1.0 μm, PM10 particulate matter <10 μm in diameter, elemental EC and organic carbon OC, gaseous pollutants nitrogen monoxide NO, nitrogen dioxide NO2, carbon monoxide CO, and sulphur dioxide SO2 were collected at a central monitoring site and meteorological data were received from an official network. For each person and visit the individual 24-hour average of pollutants immediately preceding the blood withdrawal lag 0 up to day 5 lag1-4 and 5-day running means were calculated.

ResultsIncreased levels of fibrinogen were observed for an increase in one interquartile range of UFP, PM10, EC, OC, CO, and NO revealing the strongest effect for lag 3. E-selectin increased in association with ACP and PM10 with a delay of one day. The ACP effect was also seen with the 5-day-mean. The pattern found for D-dimer was inconsistent. Prothrombin fragment 1+2 decreased with lag 4 consistently for all particulate pollutants. Von Willebrand factor antigen vWF showed a consistent decrease in association with almost all air pollutants with all lags except for lag 0. No associations were found for C-reactive protein, soluble intercellular adhesion molecule 1, serum amyloid A and factor VII.

ConclusionThese results suggest that elevated concentrations of air pollution are associated with changes in some blood markers of inflammation and coagulation in patients with chronic pulmonary disease. The clinical implications of these findings need further investigation.

Electronic supplementary materialThe online version of this article doi:10.1186-1743-8977-6-25 contains supplementary material, which is available to authorized users.

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Autor: Katharina Hildebrandt - Regina Rückerl - Wolfgang Koenig - Alexandra Schneider - Mike Pitz - Joachim Heinrich - Victor Mar


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