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BMC Infectious Diseases

, 9:168

First Online: 15 October 2009Received: 14 May 2009Accepted: 15 October 2009


BackgroundThere is little information about influenza disease among the Cambodian population. To better understand the dynamics of influenza in Cambodia, the Cambodian National Influenza Center NIC was established in August 2006. To continuously monitor influenza activity, a hospital based sentinel surveillance system for ILI influenza like illness with a weekly reporting and sampling scheme was established in five sites in 2006. In addition, hospital based surveillance of acute lower respiratory infection ALRI cases was established in 2 sites.

MethodsThe sentinel sites collect weekly epidemiological data on ILI patients fulfilling the case definition, and take naso-pharyngeal specimens from a defined number of cases per week. The samples are tested in the Virology Unit at the Institut Pasteur in Phnom Penh. From each sample viral RNA was extracted and amplified by a multiplex RT-PCR detecting simultaneously influenza A and influenza B virus. Influenza A viruses were then subtyped and analyzed by hemagglutination inhibition assay. Samples collected by the ALRI system were tested with the same approach.

ResultsFrom 2006 to 2008, influenza circulation was observed mainly from June to December, with a clear seasonal peak in October shown in the data from 2008.

ConclusionInfluenza activity in Cambodia occurred during the rainy season, from June to December, and ended before the cool season extending usually from December to February. Although Cambodia is a tropical country geographically located in the northern hemisphere, influenza activity has a southern hemisphere transmission pattern. Together with the antigenic analysis of the circulating strains, it is now possible to give better influenza vaccination recommendation for Cambodia.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2334-9-168 contains supplementary material, which is available to authorized users.

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Autor: Sek Mardy - Sovann Ly - Seng Heng - Sirenda Vong - Chea Huch - Chea Nora - Nima Asgari - Megge Miller - Isabelle Bergeri


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