Role of the Fas-FasL Pathway in HIV or SIV DiseaseReportar como inadecuado

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, 6:91

First Online: 15 October 2009Received: 21 July 2009Accepted: 15 October 2009


Human immunodeficiency virus disease involves progressive destruction of host immunity leading to opportunistic infections and increased rates for malignancies. Quantitative depletion of immune cell subsets and accruing defects in cell effector functions are together responsible for immunodeficiency The broad impact of HIV reflects a similarly broad spectrum of affected cells including subsets that do not express viral receptors or support viral replication. Indirect cell killing, the destruction of uninfected cells, is one important mechanism due partly to activation of the Fas-FasL system for cell death. This death-signaling pathway is induced during HIV disease and contributes significantly to viral pathogenesis and disease.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4690-6-91 contains supplementary material, which is available to authorized users.

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Autor: Bhawna Poonia - C David Pauza - Maria S Salvato


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