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Annals of Clinical Microbiology and Antimicrobials

, 8:27

First Online: 24 October 2009Received: 26 July 2009Accepted: 24 October 2009

Abstract

BackgroundThe aims of this study were to determine the antimicrobial susceptibility patterns of urinary isolates from community acquired acute uncomplicated urinary tract infections uUTI and to evaluate which antibiotics were empirically prescribed in the outpatient management of uUTI.

MethodsAmong the patients which were admitted to outpatient clinics of Ankara University Medical Faculty, Ibni-Sina Hospital during 2005-2006, a total of 429 women between the age of 18 and 65 years old who were clinically diagnosed with uUTI and to whom prescribed empirical antibiotics were enrolled in this prospective observational study. Patients- demographical data, urine culture results, resistance rates to antimicrobial agents and prescribed empiric antimicrobial therapy were analyzed.

ResultsTotally 390 90.9% patients among all study population were requested for urine culture by their physicians. 150 38.5% of these urine cultures were positive. The most common isolated uropathogen was Escherichia coli E. coli 71.3%. The variations of uropathogens according to age and menopause status were not significantly different.

The resistance rates of E. coli isolates for ampicillin, ampicillin-sulbactam, amoxicillin-clavulonate, cefuroxime, ceftriaxone, fluoroquinolones FQ, co-trimoxazole TMP-SMX and gentamicin were 55.1%, 32.7%, 32.7%, 23.4%, 15.9%, 25.2%, 41.1%, 6.1% respectively. FQ were the most common prescribed antibiotics 77.9% P < 0.001, followed by TMP-SMX 10.7%, fosfomycin 9.2%, nitrofurantoin 2.1%. Treatment durations were statistically longer than the recommended 3-day course P < 0.001.

ConclusionEmpirical use of FQ in uUTI should be discouraged because of increased antimicrobial resistance rates.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-0711-8-27 contains supplementary material, which is available to authorized users.

Cenk Aypak, Adalet Altunsoy and Nurşen Düzgün contributed equally to this work.

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Autor: Cenk Aypak - Adalet Altunsoy - Nurşen Düzgün

Fuente: https://link.springer.com/



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