Spatial risk profiling of Plasmodium falciparum parasitaemia in a high endemicity area in Côte dIvoireReportar como inadecuado

Spatial risk profiling of Plasmodium falciparum parasitaemia in a high endemicity area in Côte dIvoire - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Malaria Journal

, 8:252

First Online: 11 November 2009Received: 03 August 2009Accepted: 11 November 2009


BackgroundThe objective of this study was to identify demographic, environmental and socioeconomic risk factors and spatial patterns of Plasmodium falciparum parasitaemia in a high endemicity area of Africa, and to specify how this information can facilitate improved malaria control at the district level.

MethodsA questionnaire was administered to about 4,000 schoolchildren in 55 schools in western Côte d-Ivoire to determine children-s socioeconomic status and their habit of sleeping under bed nets. Environmental data were obtained from satellite images, digitized ground maps and a second questionnaire addressed to school directors. Finger prick blood samples were collected and P. falciparum parasitaemia determined under a microscope using standardized, quality-controlled methods. Bayesian variogram models were utilized for spatial risk modelling and mapping of P. falciparum parasitaemia at non-sampled locations, assuming stationary and non-stationary underlying spatial dependence.

ResultsTwo-thirds of the schoolchildren were infected with P. falciparum and the mean parasitaemia among infected children was 959 parasites-μ l of blood. Age, socioeconomic status, not sleeping under a bed net, coverage rate with bed nets and environmental factors e.g., normalized difference vegetation index, rainfall, land surface temperature and living in close proximity to standing water were significantly associated with the risk of P. falciparum parasitaemia. After accounting for spatial correlation, age, bed net coverage, rainfall during the main malaria transmission season and distance to rivers remained significant covariates.

ConclusionIt is argued that a massive increase in bed net coverage, particularly in villages in close proximity to rivers, in concert with other control measures, is necessary to bring malaria endemicity down to intermediate or low levels.

List of abbreviationsACTArtemisinin-based Combination Therapy

ADDSAfrica Data Dissemination Service

AICAkaike Information Criterion

BCIBayesian Credible Interval

CIConfidence Interval

DALYsDisability-Adjusted Life Years

DEMDigital Elevation Model

DICDeviance Information Criterion

GISGeographical Information system

GPSGlobal Positioning System

ITNInsecticide-Treated Nets

LLINsLong-Lasting Insecticidal Nets

LSTLand Surface Temperature

MCMCMarkov Chain Monte Carlo

MODISModerate Resolution Imaging Spectroradiometer

NDVINormalized Difference Vegetation Index

RFERainfall Estimates

SRTMShuttle Radar Topography Mission.

Electronic supplementary materialThe online version of this article doi:10.1186-1475-2875-8-252 contains supplementary material, which is available to authorized users.

Giovanna Raso, Kigbafori D Silué contributed equally to this work.

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Autor: Giovanna Raso - Kigbafori D Silué - Penelope Vounatsou - Burton H Singer - Ahoua Yapi - Marcel Tanner - Jürg Utzinger -


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