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BMC Nephrology

, 10:39

First Online: 24 November 2009Received: 21 August 2009Accepted: 24 November 2009

Abstract

BackgroundAlthough health-related quality of life HRQOL is a potential independent predictor of mortality, nephrologists have shown little interest in HRQOL with respect to mortality in chronic kidney disease CKD. The aim of this article is to evaluate the impact of HRQOL on mortality in the elderly, who are likely to develop or already have CKD.

MethodsAmong 1,000 randomly sampled participants aged more than 65 years sourced from the Korean Longitudinal Study on Health and Ageing, 944 subjects were evaluated for HRQOL. HRQOL was assessed using a 36-item Short-Form health survey SF36. A cumulative survival rate was calculated according to tertiles of SF36 scores and classified by the presence of CKD estimated GFR <60 ml-min-1.73 m.

ResultsAmong 944 subjects, 46.6% had CKD. CKD patients had lower total and physical component scores compared with subjects without CKD. The 3-year cumulative survival rate was 90.0% non-CKD vs. CKD: 92.6% vs. 87.4%, P = 0.005 by log rank test. After adjusting for multiple variables, a reduced SF36 score physical and mental components was a strong predictor of all-cause mortality. Physical components were consistently able to predict mortality after CKD classification, but mental components were statistically significant only in the CKD group.

ConclusionIn addition to traditional risk factors of mortality, nephrologists should be aware of HRQOL as a predictor of mortality and should make efforts to improve HRQOL in CKD patients.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2369-10-39 contains supplementary material, which is available to authorized users.

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Autor: Seung Seok Han - Ki Woong Kim - Ki Young Na - Dong-Wan Chae - Yon Su Kim - Suhnggwon Kim - Ho Jun Chin

Fuente: https://link.springer.com/







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