Prevalence of tick-borne encephalitis virus antibodies in dogs from DenmarkReportar como inadecuado

Prevalence of tick-borne encephalitis virus antibodies in dogs from Denmark - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Acta Veterinaria Scandinavica

, 51:56

First Online: 29 December 2009Received: 26 August 2009Accepted: 29 December 2009


BackgroundLarge regions of central and eastern Europe are recognized as areas where tick-borne encephalitis virus TBEV is endemic, including countries neighbouring Denmark. It is therefore timely and relevant to determine if TBEV infections occur in Denmark. This study investigates the presence of antibodies against TBEV in a cross-section of the Danish canine population to assess the level of exposure to TBEV and possibly identify TBEV microfoci in Denmark.

MethodsBlood samples were collected from 125 dogs originating from five regions of Denmark between November 2005 and March 2006. Serum was tested by indirect ELISA. All positive and borderline samples were re-evaluated by neutralisation test NT.

ResultsThe prevalence of TBEV serocomplex antibodies was 30% by ELISA and 4.8% by NT with 100%-neutralising capacity. The island of Bornholm was the only area in Denmark with NT positive samples.

ConclusionsThe island of Bornholm is an area with a high risk of encountering TBEV microfoci. The presence of TBEV serocomplex antibodies in many sentinel animals from other parts of Denmark points toward existence of other TBEV microfoci. Discrepancies found between ELISA and NT results stress the importance of careful evaluation of serological tests, when interpreting results.

AbbreviationsTBEVTick-borne encephalitis virus

ELISAEnzyme-linked immunosorbent assay

NTNeutralisation test

Electronic supplementary materialThe online version of this article doi:10.1186-1751-0147-51-56 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Autor: Katherine ES Lindhe - Danny S Meldgaard - Per M Jensen - Geoffrey A Houser - Mette Berendt


Documentos relacionados