Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection courseReportar como inadecuado




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Retrovirology

, 5:33

First Online: 17 April 2008Received: 29 February 2008Accepted: 17 April 2008

Abstract

Immunotherapy of feline immunodeficiency virus FIV-infected cats with monocyte-derived dendritic cells MDCs loaded with aldrithiol-2 AT2-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4 T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4690-5-33 contains supplementary material, which is available to authorized users.

Giulia Freer, Donatella Matteucci contributed equally to this work.

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Autor: Giulia Freer - Donatella Matteucci - Paola Mazzetti - Francesca Tarabella - Enrica Ricci - Leonia Bozzacco - Antonio Merico

Fuente: https://link.springer.com/



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