The effect of acute hyperglycemia on retinal thickness and ocular refraction in healthy subjectsReportar como inadecuado

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Graefe-s Archive for Clinical and Experimental Ophthalmology

, Volume 246, Issue 5, pp 703–708

First Online: 25 January 2008Received: 03 October 2007Revised: 02 November 2007Accepted: 05 November 2007


PurposeTo quantify the retinal thickness and the refractive error of the healthy human eye during hyperglycemia by means of optical coherence tomography OCT and Hartmann–Shack aberrometry.

MethodsHyperglycemia was induced in five healthy subjects who were given a standard oral glucose tolerance test OGTT after a subcutaneous injection of somatostatin. Main outcome parameters were the central, pericentral and peripheral thickness of the fovea, measured by means of optical coherence tomography OCT3. Ocular refractive error was determined with Hartmann-Shack aberrometry. Measurements at baseline and during maximal hyperglycemia were analyzed, and a change was considered clinically significant if the difference between the measurements exceeded the threshold of 50 μm for retinal thickness and 0.2 D for refractive error.

ResultsDuring hyperglycemia mean blood glucose level at baseline: 4.0 mmol-l; mean maximal blood glucose level: 18.4 mmol-l no significant changes could be found in the central, pericentral, or peripheral foveal thickness in any of the five subjects. One of the subjects had a hyperopic shift of 0.4 D, but no significant change in refractive error was found in any of the other subjects.

ConclusionsThe present study shows that in healthy subjects induced hyperglycemia does not affect retinal thickness, but it can cause a small hyperopic shift of refraction.

KeywordsHyperglycemia Diabetes mellitus Optical coherence tomography Refractive errors The authors had no financial support for this study. There are no conflicts of interest.

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Autor: Nanouk G. M. Wiemer - Elisabeth M. W. Eekhoff - Suat Simsek - Robert J. Heine - Peter J. Ringens - Bettine C. P. Pol


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