Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: cohort analysis of the ProActive trialReportar como inadecuado

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, Volume 51, Issue 5, pp 787–794

First Online: 04 March 2008Received: 22 October 2007Accepted: 16 January 2008


Aims-hypothesisOur aim was to examine the association between change in physical activity energy expenditure PAEE, total body movement counts per day and aerobic fitness maximum oxygen consumption \{\mathop {\text{V}}\limits^{\text{.}} }{\text{O}} {{2\max }} \ over 1 year and metabolic risk among individuals with a family history of diabetes.

MethodsThree hundred and sixty-five offspring of people with type 2 diabetes underwent measurement of energy expenditure PAEE measured using the flex heart rate method, total body movement daily activity counts from accelerometry data, \{\mathop {\text{V}}\limits^{\text{.}} }{\text{O}} {{2\max }} \ predicted from a submaximal graded treadmill exercise test and anthropometric and metabolic status at baseline and 1 year n = 321 in the ProActive trial. Clustered metabolic risk was calculated by summing standardised values for waist circumference, fasting triacylglycerol, insulin and glucose, blood pressure and the inverse of HDL-cholesterol. Linear regression was used to quantify the association between changes in PAEE, total body movement and fitness and clustered metabolic risk at follow-up.

ResultsParticipants increased their activity by 0.01 units PAEE kJ kg day over 1 year. Total body movement increased by an average of 9,848 counts per day. Change in total body movement β = −0.066, p = 0.004 and fitness β = −0.056, p = 0.003 was associated with clustered metabolic risk at follow-up, independently of age, sex, smoking status, socioeconomic status and baseline metabolic score.

Conclusions-interpretationSmall increases in activity and fitness were associated with a reduction in clustered metabolic risk in this cohort of carefully characterised at-risk individuals. Further research to quantify the reduction in risk of type 2 diabetes associated with feasible changes in these variables should inform preventive interventions.

Clinical trial registration number: ISRCTN61323766.

KeywordsCardio-respiratory fitness Fitness Metabolic risk Metabolic syndrome Physical activity Syndrome X AbbreviationsEEenergy expenditure

FFMfat-free mass

HRheart rate

PAEEphysical activity energy expenditure

REEresting energy expenditure

SESsocioeconomic status

\{\mathop {\text{V}}\limits^{\text{.}} }{\text{O}} {{2\max }} \maximum oxygen consumption

zMScontinuously distributed metabolic risk variable

zMS-obcontinuously distributed metabolic risk variable without the adiposity component waist circumference

The other members of the ProActive research team, besides the authors, are listed in Acknowledgements.

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Autor: R. K. Simmons - S. J. Griffin - R. Steele - N. J. Wareham - U. Ekelund - On behalf of the ProActive Research Team


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