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European Journal of Clinical Pharmacology

, 64:987

First Online: 02 July 2008Received: 23 January 2008Accepted: 22 April 2008

Abstract

PurposeWe compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria.

MethodsTwelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base-kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twenty-five women completed the pharmacokinetic study.

ResultsAlthough increasing gestational age was associated with reduced chloroquine \{\text{AUC}} {0 \to \infty } \, there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women. Fever was associated with lower chloroquine \{\text{AUC}} {0 \to \infty } \ values. Desethylchloroquine area under the curve AUC values were not significantly affected by pregnancy.

ConclusionsPregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria.

KeywordsMalaria Plasmodium vivax Chloroquine Pharmacokinetics Pregnancy  Download fulltext PDF



Autor: Sue Jean Lee - Rose McGready - Christine Fernandez - Kasia Stepniewska - Moo Koo Paw - Samuel Jacher Viladpai-nguen - Kya

Fuente: https://link.springer.com/







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