Conventional and Dense Gas Techniques for the Production of Liposomes: A ReviewReportar como inadecuado

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AAPS PharmSciTech

, 9:798

First Online: 03 July 2008Received: 27 October 2007Accepted: 24 March 2008


The aim of this review paper is to compare the potential of various techniques developed for production of homogenous, stable liposomes. Traditional techniques, such as Bangham, detergent depletion, ether-ethanol injection, reverse-phase evaporation and emulsion methods, were compared with the recent advanced techniques developed for liposome formation. The major hurdles for scaling up the traditional methods are the consumption of large quantities of volatile organic solvent, the stability and homogeneity of the liposomal product, as well as the lengthy multiple steps involved. The new methods have been designed to alleviate the current issues for liposome formulation. Dense gas liposome techniques are still in their infancy, however they have remarkable advantages in reducing the use of organic solvents, providing fast, single-stage production and producing stable, uniform liposomes. Techniques such as the membrane contactor and heating methods are also promising as they eliminate the use of organic solvent, however high temperature is still required for processing.

Key wordsdense gas technology drug delivery liposomes nano-particles phospholipid  Download fulltext PDF

Autor: Louise A. Meure - Neil R. Foster - Fariba Dehghani


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