Role of retinoic receptors in lung carcinogenesisReportar como inadecuado

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Journal of Experimental and Clinical Cancer Research

, 27:18

First Online: 14 July 2008Received: 06 May 2008Accepted: 14 July 2008


Several in vitro and in vivo studies have examined the positive and negative effects of retinoids vitamin A analogs in premalignant and malignant lesions. Retinoids have been used as chemopreventive and anticancer agents because of their pleiotropic regulator function in cell differentiation, growth, proliferation and apoptosis through interaction with two types of nuclear receptors: retinoic acid receptors and retinoid X receptors. Recent investigations have gradually elucidated the function of retinoids and their signaling pathways and may explain the failure of earlier chemopreventive studies.

In this review we have compiled basic and recent knowledge regarding the role of retinoid receptors in lung carcinogenesis. Sensitive and appropriate biological tools are necessary for screening the risk population and monitoring the efficacy of chemoprevention. Investigation of retinoid receptors is important and may contribute to the establishment of new strategies in chemoprevention for high-risk patients and in the treatment of lung cancer.

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Autor: Krisztina Bogos - Ferenc Renyi-Vamos - Gabor Kovacs - Jozsef Tovari - Balazs Dome


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