Effects of acute tryptophan depletion on affective processing in first-degree relatives of depressive patients and controls after exposure to uncontrollable stressReportar como inadecuado




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Psychopharmacology

, Volume 199, Issue 2, pp 151–160

First Online: 13 June 2008Received: 08 November 2007Accepted: 25 February 2008

Abstract

RationaleIndividuals with a family history of depression may be more likely to develop depression due to an innate vulnerability of their serotonergic system. However, even though serotonergic vulnerability may constitute a risk factor in the development of depression, it does not seem to be sufficient to cause a depressive episode. Based on previous data, it is suggested that stress may be a mediating factor.

ObjectivesThis study examined the role of serotonin 5-HT in stress coping in individuals with or without a family history of depression.

Materials and methodsNineteen healthy first-degree relatives of depressive patients FH+ and 19 healthy controls without a family history of depression FH− were tested in a double-blind placebo-controlled design for affective processing under acute stress exposure, following acute tryptophan depletion ATD or placebo.

ResultsSignificant negative effects were found of stress on affective processing in FH− and FH+. In addition, FH− responded slower to positive words after stress only following ATD, whereas FH+ responded marginally slower under stress already after placebo and before stress following ATD.

ConclusionAcute stress exposure reduces positive affective bias; supporting the role of stress as an important predecessor in the development of depression. Furthermore, FH+ may be more susceptible than FH− to the negative effects of stress as well as to the negative effects of ATD. The results support the assumption that the 5-HT system is involved in stress resilience and may be more vulnerable in first-degree relatives of depression.

KeywordsSerotonin Major depression Tryptophan depletion Family history Stress Vulnerability  Download fulltext PDF



Autor: Christine Firk - C. Rob Markus

Fuente: https://link.springer.com/







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