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Journal of Neuro-Oncology

, 91:59

First Online: 19 August 2008Received: 27 April 2008Accepted: 04 August 2008


Background Myeloid sarcoma is an extramedullary manifestation of haematologic malignancy, most commonly acute myeloid leukemia AML, which can cause neurological symptoms. Case description A 45-year-old male with a history of AML presented with a lumbosacral nerve root entrapment syndrome followed by cauda equina compression, but without systemic signs of AML recurrence. MRI showed a mass compressing the spinal cord at level L5–S2. After surgically removing the tumour pathologic examination yielded a myeloid sarcoma. Combined chemotherapy and radiation therapy followed. Five months later the patient developed a thoracal Th10–Th11 radiculopathy due to a relapse of the myeloid sarcoma, followed by C8-Th1-radiculopathy caused by leptomeningeal spread. Conclusion This case forms the first description of recurrent, multifocal and progressive radiculopathy due to myeloid sarcoma. This diagnosis should be considered in patients with radiculopathy with previous haematological malignancy and-or signs or symptoms of such disease; the absence of systemic disease activity does not rule out myeloid sarcoma.

KeywordsMyeloid sarcoma Granulocytic sarcoma Chloroma Nerve root entrapment Radiculopathy Acute myeloid leukemia AbbreviationsAMLAcute myeloid leukemia

CNSCentral nervous system

CSFCerebrospinal fluid

DLIDonor lymphcyte infusion

GVHDGraft versus host disease

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Autor: Wiebe C. Verra - Tom J. Snijders - Tatjana Seute - K. Sen Han - H. Karel Nieuwenhuis - Geert Jan Rutten


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