Concentrations of cardiac Troponin I before and after ovariohysterectomy in 46 female dogs with pyometraReportar como inadecuado

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Acta Veterinaria Scandinavica

, 50:35

First Online: 11 September 2008Received: 17 March 2008Accepted: 11 September 2008


BackgroundCanine pyometra is a common disease in countries where routine spaying of young dogs is not common practice. This disease is known to lead to systemic inflammation potentially affecting multiple organs in the body, including the heart. Cardiac-specific Troponin I cTnI is a sensitive marker of myocardial cell damage, which can result from ischemia, trauma, toxins or inflammation. Dogs with pyometra are also exposed to anaesthesia which can potentially result in myocardial cell damage. The aims of the study were 1 to evaluate the occurrence of myocardial cell damage as indicated by increased serum concentrations of cTnI in dogs with pyometra and relate these to presence of systemic inflammation and 2 to evaluate the change in cTnI-concentrations after anaesthesia and surgery.

MethodsSerum cTnI concentration was measured preoperatively and one day after surgery in 46 female dogs with pyometra and 15 female dogs that underwent surgery for other reasons ovariohysterectomy and mammary tumours.

ResultsForty-six female dogs of different breeds diagnosed with pyometra were included. The dogs had a median age of 8.5 years IQR 7.5–10 and a median weight of 29 kg IQR 9–32. Of the 46 dogs, 37 80% fulfilled the chosen criteria for systemic inflammatory response syndrome SIRS at inclusion. Thirteen 28% of the dogs had increased cTnI concentrations > 0.2 μg-l before surgery and 18 39% had increased cTnI-concentrations the day after surgery. The cTnI concentrations in the 13 dogs with increased preoperative cTnI concentrations decreased in 8 dogs, increased in 4 dogs, and was unchanged in one dog. Seven dogs with nondetectable preoperative cTnI concentrations had increased postoperative concentrations. The only significant association between the studied laboratory or clinical variables including SIRS and cTnI concentration was preoperative percentage band neutrophils PBN and postoperative cTnI concentration P = 0.016. In total, 20 dogs 43% had increased pre- or postoperative cTnI concentrations. Seven dogs 15% had pre-or postoperative concentrations of cTnI of 1.0 μg-l or higher.

ConclusionMild to moderate increases in cTnI appears to be common in dogs with pyometra before and after surgery, but the clinical importance of this finding is uncertain. None of the studied clinical variables were found to reliably predict increased preoperative cTnI concentrations. Because of the pre- and postoperative variation in cTnI concentrations, it was not possible to identify a negative effect of anaesthesia and surgery on myocardial cell integrity.

Electronic supplementary materialThe online version of this article doi:10.1186-1751-0147-50-35 contains supplementary material, which is available to authorized users.

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Autor: Lena Pelander - Ragnvi Hagman - Jens Häggström


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