Size dependent heat generation of magnetite nanoparticles under AC magnetic field for cancer therapyReport as inadecuate

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BioMagnetic Research and Technology

, 6:4

First Online: 20 October 2008Received: 16 April 2008Accepted: 20 October 2008


BackgroundWe have developed magnetic cationic liposomes MCLs that contained magnetic nanoparticles as heating mediator for applying them to local hyperthermia. The heating performance of the MCLs is significantly affected by the property of the incorporated magnetite nanoparticles. We estimated heating capacity of magnetite nanoparticles by measuring its specific absorption rate SAR against irradiation of the alternating magnetic field AMF.

MethodMagnetite nanoparticles which have various specific-surface-area SSA are dispersed in the sample tubes, subjected to various AMF and studied SAR.

ResultHeat generation of magnetite particles under variable AMF conditions was summarized by the SSA. There were two maximum SAR values locally between 12 m-g to 190 m-g of the SSA in all ranges of applied AMF frequency and those values increased followed by the intensity of AMF power. One of the maximum values was observed at approximately 90 m-g of the SSA particles and the other was observed at approximately 120 m-g of the SSA particles. A boundary value of the SAR for heat generation was observed around 110 m-g of SSA particles and the effects of the AMF power were different on both hand. Smaller SSA particles showed strong correlation of the SAR value to the intensity of the AMF power though larger SSA particles showed weaker correlation.

ConclusionThose results suggest that two maximum SAR value stand for the heating mechanism of magnetite nanoparticles represented by hysteresis loss and relaxation loss.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-044X-6-4 contains supplementary material, which is available to authorized users.

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Author: Jun Motoyama - Toshiyuki Hakata - Ryuji Kato - Noriyuki Yamashita - Tomio Morino - Takeshi Kobayashi - Hiroyuki Honda



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