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Radiation Oncology

, 3:35

First Online: 20 October 2008Received: 28 July 2008Accepted: 20 October 2008

Abstract

BackgroundTo report acute and late toxicity in prostate cancer patients treated by dose escalated intensity-modulated radiation therapy IMRT and organ tracking.

MethodsFrom 06-2004 to 12-2005 39 men were treated by 80 Gy IMRT along with organ tracking. Median age was 69 years, risk of recurrence was low 18%, intermediate 21% and high in 61% patients. Hormone therapy HT was received by 74% of patients. Toxicity was scored according to the CTC scale version 3.0. Median follow-up FU was 29 months.

ResultsAcute and maximal late grade 2 gastrointestinal GI toxicity was 3% and 8%, late grade 2 GI toxicity dropped to 0% at the end of FU. No acute or late grade 3 GI toxicity was observed. Grade 2 and 3 pre-treatment genitourinary GU morbidity PGUM was 20% and 5%. Acute and maximal late grade 2 GU toxicity was 56% and 28% and late grade 2 GU toxicity decreased to 15% of patients at the end of FU. Acute and maximal late grade 3 GU toxicity was 8% and 3%, respectively. Decreased late ≥ grade 2 GU toxicity free survival was associated with higher age P = .025, absence of HT P = .016 and higher PGUM P < .001.

DiscussionGI toxicity rates after IMRT and organ tracking are excellent, GU toxicity rates are strongly related to PGUM.

Electronic supplementary materialThe online version of this article doi:10.1186-1748-717X-3-35 contains supplementary material, which is available to authorized users.

Pirus Ghadjar, Jacqueline Vock contributed equally to this work.

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Autor: Pirus Ghadjar - Jacqueline Vock - Daniel Vetterli - Peter Manser - Roland Bigler - Jan Tille - Axel Madlung - Frank Behren

Fuente: https://link.springer.com/







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