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Lipids in Health and Disease

, 7:42

First Online: 03 November 2008Received: 24 July 2008Accepted: 03 November 2008

Abstract

BackgroundThere is a belief among some society that opium has a number of beneficial effects on cardiovascular disease. The aim of the present investigation as a cross-sectional study was to assess this hypothesis. Several biochemical factors Fasting blood sugar, Cholesterol, Triglyceride, LDL-Cholesterol, HDL-Cholesterol, HbA1C, CRP, Fibrinogen, Factor VII, SGOT, SGPT, Lpa, apo A and apo B were evaluated in opium-addicted men case against non opium-addicted mencontrol. Three hundred and sixty opium-addicted men were divided into three groups according to the route of administration Orally, Vafour and Sikh-Sang and each group was divided into four subgroups according to the duration of addiction 5 months, 1 year, 2 years and 5 years. Blood morphine concentration was measured by ELISA method.

ResultsThe results show that morphine concentration was significantly higher in orally administration. In all routes, there was a direct correlation between blood morphine concentration and period of addiction. Regardless to the period and route of administration, the level of HbA1C, CRP, factor VII, Fibrinogen, apo B, Lpa, SGOT, and SGPT were significantly higher in the case subjects as compared with controls and HDL-Cholesterol and apo a were significantly lower in the case subjects.

ConclusionThis study demonstrated the deleterious effects of opium on some traditional and new cardiovascular disease risk factors. These deleterious effects are related to the period of addiction and their levels are significantly increased after 2 years of addiction. Route of administration impresses cardiovascular risk factors and -Sikh-Sang- showed the worst effect.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-511X-7-42 contains supplementary material, which is available to authorized users.

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Autor: Sedigheh Asgary - Nizal Sarrafzadegan - Gholam-Ali Naderi - Reza Rozbehani

Fuente: https://link.springer.com/



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