Laryngeal Squamous Cell Carcinoma in a 13 Year-Old Child Associated with Human Papillomaviruses 16 and 18: A Case Report and Review of the LiteratureReportar como inadecuado




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Head and Neck Pathology

, 3:37

First Online: 22 November 2008Received: 05 August 2008Accepted: 03 November 2008

Abstract

Squamous cell carcinoma SCC of the larynx is extremely rare in adolescents and typically has an aggressive nature. The mechanism of laryngeal oncogenesis is complex and little is known about the role that human papillomavirus HPV plays in SCC in adolescents. We report a case of invasive laryngeal SCC that co-expressed HPV DNA subtypes 16 and 18 in a 13 year-old boy. Detection of HPV DNA types 6, 11, 16, 18, 31, 33, and 51 was performed by in situ hybridization, with confirmation by polymerase chain reaction. Immunohistochemical staining with p16 and HPV 16-18 revealed diffusely positive staining in the tumor cells. Coinfection by HPV DNA types 16 and 18 has not been previously reported, but our case suggests that HPV is a risk factor in developing laryngeal SCC in children and adolescents. Future studies evaluating HPV in the pathogenesis of these lesions is recommended to determine its prognostic significance.

KeywordsLaryngeal carcinoma in adolescents Vocal cord Hoarseness Squamous cell carcinoma Human papillomavirus HPV P16 Translocation 15;19  Download fulltext PDF



Autor: Beth Joos - Nathan Joos - Jeffrey Bumpous - Carolyn Burns - Christopher A. French - Hanan Farghaly

Fuente: https://link.springer.com/



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