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Health and Quality of Life Outcomes

, 6:110

First Online: 04 December 2008Received: 05 August 2008Accepted: 04 December 2008


ObjectiveWe examined whether adiposity and fitness explain the decrease in health-related quality of life HRQOL associated with type 2 diabetes mellitus.

MethodsThis was a cross-sectional study using baseline data from two exercise training interventions. One study enrolled people with and the other without type 2 diabetes. We assessed aerobic fitness -fitness- as peak oxygen uptake during treadmill testing, adiposity -fatness- as percentage of total body fat by dual-energy x-ray absorptiometry, and HRQOL by the Medical Outcomes Study SF-36. Bivariate and multivariate linear regression analyses were used examine determinants of HRQOL were used to examine determinants of HRQOL.

ResultsThere were 98 participants with and 119 participants without type 2 diabetes. Participants with type 2 diabetes had a mean hemoglobin A1c of 6.6% and, compared with participants without diabetes had lower HRQOL on the physical component summary score P = 0.004, role-physical P = 0.035, vitality P = 0.062 and general health P < 0.001 scales after adjusting for age, sex and race. These associations of HRQOL with type 2 diabetes were attenuated by higher fitness, even more than reduced fatness. Only general health remained positively associated with type 2 diabetes after accounting for fatness or fitness P = 0.003. There were no significant differences between participants with and without diabetes in the mental component score.

ConclusionImproved fitness, even more than reduced fatness, attenuated the association of type 2 diabetes with HRQOL. The potential to improve HRQOL may motivate patients with type 2 diabetes to engage in physical activity aimed at increasing fitness. Findings from this cross-sectional analysis will be addressed in the ongoing trial of exercise training in this cohort of participants with type 2 diabetes.

Trial registrationNCT00212303

AbbreviationsBPblood pressure

DEXAdual-energy x-ray absorptiometry


Fitnessaerobic fitness

HgBA1chemoglobin A1c

HRQOLhealth-related quality of life





SDstandard deviation

Type 2 diabetestype 2 diabetes mellitus

T2DMtype 2 diabetes mellitus

VO2peakpeak oxygen uptake determined at volitional fatigue during treadmill testing.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7525-6-110 contains supplementary material, which is available to authorized users.

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Autor: Wendy L Bennett - Pamela Ouyang - Albert W Wu - Bethany B Barone - Kerry J Stewart

Fuente: https://link.springer.com/

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