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Journal of Experimental and Clinical Cancer Research

, 27:81

First Online: 04 December 2008Received: 12 June 2008Accepted: 04 December 2008

Abstract

BackgroundTreatment of cancer patients with anthracycline antibiotic doxorubicin DOX may be complicated by development of acute and chronic congestive heart failure CHF, malignant arrhythmias and death. The aim of this study was to test whether an aqueous low molecular weight LMW extract from cod muscle decreases acute mortality in the mouse model of acute CHF caused by DOX.

MethodsA LMW fraction <500 Da of the aqueous phase of cod light muscle AOX was used for treatment of male BALB-c mice ~25 g, n = 70. The animals were divided into four groups, DOX + AOX n = 20, DOX + saline NaCl n = 30, NaCl + AOX n = 10 and NaCl only n = 10. Echocardiography was performed in the separate subgroups DOX treated n = 6 and controls n = 6 to verify the presence and the grade of acute CHF. The cod extract was delivered by subcutaneously implanted osmotic minipumps over the period of 2 weeks. High-dose injection of DOX was administered to randomly selected animals. The animals received single intraperitoneal injection of DOX 25 mg-kg and were followed over two weeks for mortality.

ResultsMortality rate was 68% lower p < 0.05 in the mice treated with the extract. The analyses of cod extract have shown strong antioxidative effect in vitro.

ConclusionThe aqueous LMW cod muscles extract decreases mortality in the mouse model of DOX induced acute CHF. This effect may be mediated by cardioprotection through antioxidative mechanisms.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-9966-27-81 contains supplementary material, which is available to authorized users.

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Autor: Elmir Omerovic - Malin Linbom - Truls Råmunddal - Ann Lindgård - Ingrid Undeland - Ann-Sofie Sandberg - Bassam Soussi

Fuente: https://link.springer.com/



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