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Clinical and Molecular Allergy

, 6:13

First Online: 05 December 2008Received: 08 October 2008Accepted: 05 December 2008


Hypersensitivity to human seminal fluid is rare but can be life threatening. We report a case of IgE-mediated anaphylaxis to seminal plasma that was diagnosed by skin prick tests and successfully treated by local desensitization. A 32-year-old woman suffering from angioedema and hypotension after exposure to semen was treated with epinephrine upon admission. Skin prick tests and immunoblotting for IgE binding components showed that she was sensitized to her husband-s seminal plasma. Local desensitization, which persisted for six months, was achieved by intravaginal administration of serial dilutions of her husband-s seminal plasma.

Electronic supplementary materialThe online version of this article doi:10.1186-1476-7961-6-13 contains supplementary material, which is available to authorized users.

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Autor: Jaechun Lee - Sohyung Kim - Miok Kim - Young-Bae Chung - Jung-Sik Huh - Chul Min Park - Keun Hwa Lee - Jeong Hong Kim


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