Adherence to highly active antiretroviral therapy and its correlates among HIV infected pediatric patients in EthiopiaReportar como inadecuado

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BMC Pediatrics

, 8:53

First Online: 06 December 2008Received: 05 August 2008Accepted: 06 December 2008


BackgroundThe introduction of combination antiretroviral therapy ART has resulted in striking reductions in HIV-related mortality. Despite increased availability of ART, children remain a neglected population. This may be due to concerns that failure to adhere appears to be related to continued viral replication, treatment failure and the emergence of drug-resistant strains of HIV. This study determines the rates and factors associated with adherence to Antiretroviral ARV Drug therapy in HIV-infected children who were receiving Highly Active Antiretroviral Therapy HAART in Addis Ababa, Ethiopia in 2008.

MethodsA cross-sectional study was conducted in five hospitals in Addis Ababa from February 18 – April 28, 2008. The study population entailed parents-caretaker and index children who were following ART in the health facilities. A structured questionnaire was used for data collection.

ResultsA total of 390 children respondents were included in the study with a response rate of 91%. The majority, equaling 205 52.6% of the children, were greater than 9 years of age. Fifty five percent of the children were girls. A total of 339 children 86.9% as reported by caregivers were adherent to antiretroviral drugs for the past 7 days before the interview. Numerous variables were found to be significantly associated with adherence: children whose parents did not pay a fee for treatment OR = 0.39 95%CI: 0.16, 0.92, children who had ever received any nutritional support from the clinic OR = 0.34 95%CI: 0.14, 0.79 were less likely to adhere. Whereas children who took co-trimoxazole medication-syrup besides ARVs OR = 3.65 95%CI: 1.24, 10.74, children who did not know their sero-status OR = 2.53 95%CI: 1.24, 5.19 and children who were not aware of their caregiver-s health problem OR = 2.45 95%CI: 1.25, 4.81 were more likely to adhere than their counterparts.

ConclusionAdherence to HAART in children in Addis Ababa was higher than other similar setups. However, there are still significant numbers of children who are non-adherent to HAART.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2431-8-53 contains supplementary material, which is available to authorized users.

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Autor: Sibhatu Biadgilign - Amare Deribew - Alemayehu Amberbir - Kebede Deribe


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