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BMC Neuroscience

, 8:1

First Online: 02 January 2007Received: 21 August 2006Accepted: 02 January 2007

Abstract

BackgroundCholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the circulation. However, the contribution of neurons and glial cells to total brain cholesterol metabolism is unknown.

ResultsUsing conditional gene inactivation in the mouse, we disrupted the squalene synthase gene fdft1, which is critical for cholesterol synthesis, in cerebellar granule cells and some precerebellar nuclei. Mutant mice showed no histological signs of neuronal degeneration, displayed ultrastructurally normal synapses, and exhibited normal motor coordination. This revealed that these adult neurons do not require cell-autonomous cholesterol synthesis for survival or function.

ConclusionWe conclude that at least some adult neurons no longer require endogenous cholesterol synthesis and can fully meet their cholesterol needs by uptake from their surrounding. Glia are a likely source of cholesterol in the central nervous system.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2202-8-1 contains supplementary material, which is available to authorized users.

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Autor: Ursula Fünfschilling - Gesine Saher - Le Xiao - Wiebke Möbius - Klaus-Armin Nave

Fuente: https://link.springer.com/



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