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World Journal of Surgical Oncology

, 5:16

First Online: 05 February 2007Received: 05 December 2006Accepted: 05 February 2007

Abstract

BackgroundSporadic renal cell carcinoma RCC is rare in young adults. In the present retrospective study we reviewed clinicopathological features and disease specific survival rates in young patients ≤45 years with RCC and compared them to old patients ≥75 years with RCC.

MethodsBetween 1992 and 2005 a total of 1042 patients were treated for RCC at our institution. We found 70 patients 45 years or younger YP and 150 patients 75 years or older OP at time of diagnosis. There were no differences in therapeutical approaches between both groups. Clinical and biologic parameters at diagnosis were compared and subjected to uni- and multivariate analysis to study cancer specific survival and progression rate. Mean postoperative follow-up in both groups was 50.1 months.

ResultsMean age was 39 years in YP and 80 years in OP, respectively. YP demonstrated significantly lower stage pT1-pT2 N0 M0, p = 0.03, lower tumor grade p = 0.01 and higher male-to-female ratio p < 0.001. The rate of lymph node metastases or distant metastatic disease at presentation did not differ significantly between both groups. In multivariate analysis young age was independently associated with a higher 5-year cancer specific survival 95.2% vs. 72.3%, p = 0.009 and a lower 5-year progression rate 11.3% vs. 42.5%, p = 0.002.

ConclusionSporadic RCC in young patients have lower tumor stages and grades and a better outcome compared to elderly. Age≤45 years was an independent prognostic factor for survival and progression.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7819-5-16 contains supplementary material, which is available to authorized users.

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Autor: Stefan Denzinger - Wolfgang Otto - Maximilian Burger - Christine Hammerschmied - Kerstin Junker - Arndt Hartmann - Wolf F 

Fuente: https://link.springer.com/







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